A profound discovery with significant implications for respiratory and GI disease
Epithelial transmembrane proteins (ETPs) give functionality to tissues.
ETPs can become dysregulated by congenital disease or acquired stressors, leading to tissue dysfunction.
Four pillars of ETP Functionality
Absorption
The process by which ETPs are selectively modulated to enhance or inhibit tissue uptake of substances important for healthy epithelial tissue function, e.g., uptake of electrolyte and fluid into intestinal epithlial
Secretion
The process by which ETPs are selectively modulated to enhance or inhibit tissue deposition of substances important for healthy epithelial tissue function, e.g., secretion of chloride into the lung important in CF
Barrier Function
The process by which ETPs are selectively modulated to decrease tissue permeability for healthy epithelial tissue function, e.g., strengthening the tight-junctions of the intestinal epithelial for protection from pathogens
Proliferation
The process by which ETPs are selectively modulated to promote growth for healthy epithelial tissue function; e.g., stimulation of intestinal villus growth
RxAA ETP Interactions
Junctional
RxAA may act through a phosphorylation event to reliably activate tight junction ETPs and reduce tissue permeability and improve barrier function
GPCR
RxAA may act through cell surface signaling to promote a messaging cascade to the cell nucleus where ETP transcription and translation occurs, measurable as cell proliferation
Transporter
RxAA carrier-mediated transport creates an electrogenic second messenger dependent signaling pathway that reliably modulates ETPs to modulate tissue absorption
Ion Channel
RxAA may selectively bind to cell surface receptors to generate a second messenger signal mediated by cAMP or calcium flux and modulate tissue secretion
RxAA Cell Signaling
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